When I was a silly body-building weight lifter, tracking diameter of biceps (seems so silly). I would target muscles and do isolating exercises to make them stronger (again, very silly). Some muscle groups responded well, others not so much. I struggled to know why.
For example, thin wire'y calves. Lifting tons of weight on a calf-raising machine made no difference in large calf muscle size. Besides the obvious 'who cares', I thought I narrowed the reason why. The calf is a link in a chain. You can't make certain links of a chain stronger than others, it makes no sense. My Achilles tendon (through genetics? or whatever the reason) was as small as a #2 wooden pencil. People with large calves had thick thumb-width Achilles.
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Adaptation is a reMARKable thing.
A good source that describes bone mineral density, tendon and muscle adaptation, check out the book 'Brain Training For Runners'.
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